CAS Nr .: 154992-24-2 Ru-58841

RU58841, tseem hu ua PSK-3841. Nws yog ib qho tshwj xeeb uas tsis yog -steroidal androgen receptor antagonist. Nws cov khoom xyaw tseem ceeb yog cov ntshiab RU58841 monomer, nrog cov qauv molecular ntawm C₁₇H₁₈F₃N₃O₃ thiab molecular hnyav ntawm 369.34. Kev lag luam kev lag luam- qib khoom tiav yog kuaj los ntawm qib siab -kev ua haujlwm ua kua chromatography (HPLC), thiab nws cov purity ruaj khov ntawm ntau dua 98%. Lub purity ntawm kev cai{14}} ua batch tuaj yeem ncav cuag 99.9%. Thaum lub sij hawm tsim cov txheej txheem, tag nrho cov hluavtaws intermediates, hnyav hlau residues, thiab hnyav residues raug tshem tawm tag nrho, ua kom muaj kev ruaj ntseg ntawm cov khoom xyaw nquag thiab tiv thaiv kev puas tsuaj ntawm cov khoom thiab kev ua haujlwm tsis zoo. Lub siab - zoo RU58841 hmoov yog cov hmoov dawb, nrog cov hmoov zoo thiab sib xws. Nws tag nrho cov tsw yog me me, yuav luag tsis muaj irritating tsw, thiab tsuas muaj ib tug tsis tshua muaj neeg faint thawj tsw ntawm raw khoom. Lub solubility ntawm RU58841 hmoov yog sib xws nrog cov ntsiab lus hnyav ntawm cov khoom siv tshuaj pleev ib ce, thiab nws cov yam ntxwv sib cais yog ruaj khov thiab tswj tau. Nws yog insoluble hauv dej ntshiab, tab sis yooj yim soluble hauv organic solvents xws li ethanol, DMSO, thiab DMF. Nws tseem tuaj yeem ua kom ruaj khov hauv dej cawv-dej sib xyaw tshuab, haum rau feem ntau cov kua tshuaj pleev ib ce. Tom qab dissolution, cov kev daws teeb meem yog meej thiab pob tshab, tsis muaj kev cuam tshuam rau cov tsos thiab kev ntxhib los mos ntawm cov khoom tiav.

CAS 154992-24-2 ru-58841 tuaj yeem khi rau cov androgen receptors hauv cov hauv paus plaub hau ntawm tawv taub hau, thaiv kev sib xyaw ntawm DHT nrog cov hauv paus plaub hau ntawm qhov chaw, thiab txiav tawm tag nrho qhov ua rau cov plaub hau poob. Piv nrog rau cov khoom xyaw xws li minoxidil thiab finasteride, nws tsis tas yuav tswj hwm tag nrho cov tshuaj hormones hauv tib neeg lub cev. Nws tsuas yog ua rau thaj chaw thov hauv zos thiab tuaj yeem ncua kev rov qab txav ntawm cov plaub hau thiab thinning ntawm sab saum toj ntawm lub taub hau. Nws cov txiaj ntsig kev txhim kho ntawm theem nrab thiab theem nrab androgenetic alopecia yog qhov tshwj xeeb tshaj yog.

CAS 154992-24-2 ru-58841 hmoov tuaj yeem thim rov qab lub xeev me me ntawm cov hauv paus plaub hau, ua kom cov hauv paus plaub hau dormant, thiab rov ua kom cov as-ham zoo li qub thiab muaj peev xwm metabolic ntawm cov hauv paus plaub hau. Kev siv tsis tu ncua tuaj yeem ua rau cov plaub hau tuab thiab txuas ntxiv lub sijhawm ntawm cov plaub hau kev loj hlob, txo cov plaub hau poob thaum lub sij hawm so, ua rau cov plaub hau tshiab denser thiab muaj zog, thiab ua tiav cov txiaj ntsig ntawm cov plaub hau ruaj khov thiab kho cov plaub hau.

CAS 154992-24-2 ru-58841 tuaj yeem txhim kho cov teeb meem ntawm daim tawv nqaij los ntawm kev tso tawm androgen ntau dhau. Los ntawm lub zos antagonizing androgen kev ua ub no, nws tswj ntau ntau sebum secretion ntawm cov qog sebaceous, txo cov tsub zuj zuj ntawm cov roj ntau dhau ntawm tawv taub hau thiab lub ntsej muag, thiab unclogs lub clogged pores. Nws tuaj yeem txhim kho oily tawv taub hau oiliness thiab nquag dandruff. Nws kuj muaj qhov ua kom zoo thiab kho cov teeb meem ntawm daim tawv nqaij uas tshwm sim los ntawm androgens, xws li pob txuv thiab lub ntsej muag hirsutism, thiab coj mus rau hauv tus account qhov ruaj khov ntawm cov tawv taub hau thiab lub ntsej muag.

Raws li cov tseem ceeb active ingredient, Ru58841 yog dav siv nyob rau hauv lub formulation ntawm tus ntoo khaub lig- ciam teb siab- kawg cov plaub hau- ntxiv dag zog rau cov plaub hau kev loj hlob kua, cov plaub hau kev loj hlob kua, tshuaj kho tawv taub hau, thiab cov plaub hau loj hlob cream thiab lwm yam khoom.

Ru58841 tuaj yeem muab ntxiv rau cov khoom xws li roj- tswj toner, pob txuv- tshem tawm cov essence, thiab pore- kho cov tshuaj pleev ib ce rau kev tu tawv nqaij.

Ru58841 yog siv dav hauv kev kho mob kho mob ntawm cov tsev kho mob zoo nkauj thiab cov chaw tswj tawv taub hau. Nws tuaj yeem tsim tau rau hauv kev npaj kho tawv taub hau tshwj xeeb rau cov chaw kho mob thiab kev tswj xyuas tawv nqaij thiab kho cov kev daws teeb meem.

Ru58841 feem ntau yog siv rau hauv cov haujlwm tshawb fawb xws li kev tshawb fawb tshuaj plaub hau, kev txhim kho cov tshuaj tiv thaiv -androgen, thiab tshawb nrhiav cov txheej txheem ntawm kev tswj cov roj ntawm daim tawv nqaij.