Pinealon

Pinealon yog ib qho khoom siv luv luv - saw tripeptide tshwj xeeb rau lub hauv paus paj hlwb, nrog tus qauv amino acid sib lawv liag ntawm glutamic acid -aspartic acid- arginine (Glu-Asp-Arg, abbreviated li EDR). Nws yog ib yam khoom tseem ceeb hauv tebchaws Russia's Havenson peptide bio-kev tswj hwm. Raws li cov ntaub so ntswg -tshwj xeeb peptide bio- tswj hwm, Pinealon txawv ntawm cov khoom noj khoom haus peptides nyob rau hauv uas nws mus dhau cov khoom noj khoom haus yooj yim los ntawm kev koom tes ncaj qha rau hauv cellular gene qhia kev cai. Nws nkag mus rau hauv cov cell thiab cov ntaub so ntswg nuclear los ua rau lub hom phiaj cov noob, ua kom muaj kev hloov pauv ntawm cov hlwb neural -ib qho tseem ceeb ntawm qhov sib txawv ntawm feem ntau - lub hom phiaj peptides. Lub compound zoo nkaus li cov hmoov dawb zoo nrog cov dej ntws zoo heev thiab tsis muaj ntxhiab tsw; tsuas yog nyob rau hauv high concentrations nws muaj ib tug heev faint intrinsic amino acid saj. Pinealon ua kom pom cov dej solubility zoo heev, koom nrog hauv qeb ntawm cov dej siab heev -soluble peptides. Nyob rau hauv ib txwm kub thiab siab, nws dissolves sai sai hauv dej ntshiab, physiological saline, thiab PBS tsis daws teeb meem. Cov kev daws teeb meem yog qhov tseeb heev, nyob ruaj khov yam tsis muaj nag lossis daus dhau lub sijhawm ntev, thiab tiv thaiv crystallization txawm tias qhov kub thiab txias, ua rau nws tsim nyog rau ntau yam aqueous formulation systems.

Pinealon tuaj yeem nkag mus ncaj qha rau ntawm cov cell membrane thiab cov ntaub so ntswg nuclear, ua haujlwm ntawm cov tub ntxhais ntawm cov paj hlwb. Nws tuaj yeem cuam tshuam qhov tshwm sim ntawm tus kheej apoptosis ntawm paj hlwb thiab ua rau kom muaj sia nyob ntawm cov neurons. Nws tseem tuaj yeem ua lub luag haujlwm zoo hauv kev kho thiab tswj cov paj hlwb puas, tsis tu ncua tswj kev noj qab haus huv thiab ua haujlwm ntawm lub hauv nruab nrab paj hlwb.

Nws tuaj yeem tshwj xeeb tshem tawm cov kab mob ROS reactive oxygen nyob rau hauv lub paj hlwb, thaiv cov oxidative kev nyuaj siab saw cov tshuaj tiv thaiv, thiab txo qhov nruam yaig ntawm dawb radicals nyob rau hauv lub hlwb ntawm paj hlwb. Nws tseem tuaj yeem txhim kho cov haujlwm ntawm cov tshuaj tiv thaiv antioxidant xws li superoxide dismutase hauv lub cev, txhim kho qhov teeb meem ntawm neural oxidative aging.

Pinealon tuaj yeem txhim kho kev kawm muaj peev xwm thiab kev nco tsis zoo los ntawm kev laus thiab kev puas tsuaj hauv lub cev, thiab txhim kho kev txawj ntse ntawm lub hlwb. Nws tuaj yeem cuam tshuam tau zoo thiab txhim kho qhov kev paub txog kev poob qis los ntawm cov qauv kev laus, nrog rau qhov tshwm sim los ntawm kev kub siab thiab kev ua txhaum ntawm metabolic. Nws yog ib qho khoom siv zoo heev rau kev tiv thaiv - kev laus ntawm lub hlwb thiab kev txawj ntse.

Dav siv nyob rau hauv ntau yam hauv vitro cell thwmsim thiab tsiaj cov qauv kev tshawb fawb, nws tau dhau los ua ib qho ntawm cov qauv neeg sib tw cov ntaub ntawv rau kev tshawb fawb neural mechanism hauv cov tsev kawm qib siab thiab cov tsev kawm tshawb fawb thoob ntiaj teb vim nws qhov tseeb mechanism, kev sim ua kom rov ua tau zoo, thiab kev ua haujlwm ruaj khov.