NAD(nicotinamide adenine dinucleotide), kev tshawb fawb hu ua nicotinamide adenine dinucleotide, muaj nyob hauv txhua lub cell ntawm peb lub cev. NAD + yog ib qho tseem ceeb metabolite thiab coenzyme nyob rau hauv ntau yam metabolic pathways, kho thiab koom nrog ntau yam kev lom neeg. Ntau tshaj 300 enzymes nyob ntawm NAD + ua haujlwm.
NAD + ua lub tsheb thauj mus los, nqa cov hluav taws xob thiab xa lawv los ntawm ib lub xov tooj ntawm tes mus rau lwm qhov. Ua ke nrog nws cov molecular counterpart NADH, nws koom nrog ntau yam kev cuam tshuam metabolic los ntawm kev sib pauv hluav taws xob. Cov tshuaj tiv thaiv metabolic no ua rau adenosine triphosphate (ATP), lub cev "zog" molecule.
Yooj yim muab, NAD + yog qhov tseem ceeb rau kev tswj hwm kev noj qab haus huv thiab sib npaug. Metabolism, redox cov tshuaj tiv thaiv, DNA tu thiab kho, genetic stability, epigenetic regulation, thiab ntau lwm yam txheej txheem yuav tsum muaj kev koom tes ntawm NAD+.
Yog li ntawd, peb lub cev muaj qhov xav tau ntau rau NAD+. NAD + yog tas li ua ke, tawg, thiab rov ua dua tshiab hauv cov hlwb kom tswj cov qib cellular NAD + ruaj khov.
Kev sib raug zoo ntawm NAD + thiab kev laus
Coenzymes koom nrog hauv cov metabolism hauv cov khoom tseem ceeb xws li carbohydrates, rog, thiab cov proteins hauv tib neeg lub cev, ua lub luag haujlwm tseem ceeb hauv kev tswj cov khoom siv hauv tib neeg thiab lub zog metabolism thiab tswj kev ua haujlwm ntawm lub cev. NAD yog ib qho tseem ceeb tshaj plaws coenzymes hauv tib neeg lub cev, tseem hu ua coenzyme I, koom nrog ntau txhiab tus redox enzymatic cov tshuaj tiv thaiv hauv tib neeg lub cev. Nws yog ib qho tseem ceeb ntawm cov metabolism hauv txhua lub cell.
Nws cov haujlwm muaj ntau heev, thiab nws cov haujlwm tseem ceeb suav nrog:
Txhawb kev tsim khoom ntawm bioenergy
NAD + tsim ATP los ntawm kev ua pa ntawm tes, ncaj qha ntxiv lub zog ntawm tes thiab txhim kho kev ua haujlwm ntawm tes; kho cov noob
NAD + yog tib lub substrate ntawm DNA kho enzyme PARP. Cov enzymes no koom nrog hauv kev kho DNA, pab kho DNA puas thiab hlwb, txo qhov tshwm sim ntawm kev hloov pauv ntawm tes, thiab tiv thaiv qhov tshwm sim ntawm qog noj ntshav;
Ua kom tag nrho cov proteins sirtuin
NAD + tuaj yeem qhib tau tag nrho 7 sirtuin proteins, yog li NAD + muaj kev cuam tshuam tseem ceeb dua rau kev tiv thaiv - laus thiab ncua kev ua neej;
Txhim khu kev tiv thaiv kab mob
NAD + ntxiv dag zog rau lub cev tiv thaiv kab mob thiab txhim kho kev tiv thaiv kab mob ntawm tes los ntawm kev xaiv cuam tshuam rau kev ciaj sia thiab kev ua haujlwm ntawm kev tswj T hlwb.
Nws yog ib nqi sau cia hais tias nyob rau hauv ntau yam qauv kab mob, nrog rau cov nas thiab tib neeg, kev laus yog nrog los ntawm ib tug maj mam poob rau hauv cov ntaub so ntswg thiab cellular NAD + ntau ntau. Kev poob qis hauv NAD+ qib yog ua rau muaj feem cuam tshuam rau ntau lub hnub nyoog - cov kab mob ntsig txog, suav nrog kev paub tsis meej, mob qog noj ntshav, kab mob metabolic, sarcopenia, thiab frailty. NAD + qib poob qis nrog lub hnub nyoog, feem ntau vim tias nws cov nqi tsim khoom tsis tuaj yeem ua raws li nws tus nqi noj.
Ntau qhov kev tshawb fawb tau pom tias muaj kev sib raug zoo ntawm kev poob qis NAD + qib thiab ntau lub hnub nyoog - cov kab mob cuam tshuam, suav nrog kev paub txog kev poob qis, mob, mob qog noj ntshav, kab mob metabolic, sarcopenia, thiab kab mob neurodegenerative.
Kev Tshawb Fawb Keeb Kwm ntawm NAD +
NAD + tau kawm los ntawm cov kws tshawb fawb tau 100 xyoo; nws tsis yog ib qho kev tshawb pom tshiab, tab sis yog ib yam khoom uas tau tshawb fawb ntau tshaj ib puas xyoo. Nobel laureates hauv chemistry thiab tshuaj tau tso lub hauv paus rau nws txoj kev tshawb fawb.
1904: Thawj qhov kev tshawb pom ntawm NAD +
Sir Arthur Harden, British biochemist, thawj zaug tshawb pom NAD +, thiab tom qab ntawd tau txais Nobel nqi zog hauv Chemistry hauv xyoo 1929.
1920: Purification ntawm NAD + thiab nrhiav pom ntawm nws cov qauv molecular
Hans von Euler-Chelpin thawj zaug cais thiab ua kom huv NAD+ thiab nrhiav pom nws cov qauv dinucleotide, thiab tom qab ntawd tau txais Nobel nqi zog hauv Chemistry xyoo 1929.
1930: Tshawb nrhiav lub luag haujlwm tseem ceeb ntawm NAD + hauv tib neeg cov metabolism
Otto Warburg thawj zaug pom lub luag haujlwm tseem ceeb ntawm NAD + ua coenzyme hauv cov khoom siv thiab lub zog metabolism, thiab tom qab ntawd tau txais Nobel nqi zog hauv Tshuaj hauv xyoo 1931.
1980: Kev siv NAD + hauv kev kho tib neeg cov kab mob
George Birkmayer, tus xibfwb hauv Department of Medical Chemistry ntawm University of Graz, Austria, thawj zaug thov txo NAD + rau kev kho mob.
2000-2012: Tshawb nrhiav pom tias NAD + tuaj yeem txuas ntxiv lub neej ntawm ntau yam tsiaj
Cov pab pawg tshawb fawb ntawm Leonard Guarente, lub ntiaj teb- kws tshuaj muaj npe nrov Stephen L. Helfand, thiab Haim Y. Cohen feem pom tau tias NAD + tuaj yeem txuas lub neej ntawm Caenorhabditis elegans ze li 50%, ncua lub neej ntawm cov txiv hmab txiv ntoo yoov los ntawm kwv yees li 10%-20%, thiab 1 mice lub neej ntev dua ntawm txiv neej. Tau ntev, cov kws tshawb fawb tau txuas ntxiv hloov kho thiab kho lawv cov kev tshawb fawb hauv lub neej. Thaum Lub Kaum Ob Hlis 2013, David Sinclair, tus kws tshaj lij ntawm noob caj noob ces ntawm Harvard University, tau tshaj tawm cov kev tshawb fawb hauv ntiaj teb cov ntawv xov xwm kev kawm saum toj kawg nkaus *Cell*, qhia tias "tom qab ntxiv cov nas nrog NAD rau ib lub lim tiam, lawv lub neej tau txuas ntxiv los ntawm 30%. Qhov no yog thawj zaug ua qauv qhia rau pej xeem tias NAD + cov tshuaj ntxiv tuaj yeem thim rov qab kev laus thiab txuas ntxiv lub neej. Qhov kev tshawb fawb no ua rau muaj kev xav thoob ntiaj teb thiab tsim NAD cov tshuaj ntxiv rau lawv txoj hauv kev kom muaj koob meej raws li cov tshuaj tiv thaiv kev laus.
Sab laug: Cov nas noj cov tshuaj NAD Txoj Cai: Cov nas tsis noj cov tshuaj NAD
Ua tsaug rau qhov kev tshawb pom tsis txaus ntseeg no, NAD + thiab kev tiv thaiv - laus tau tsim muaj kev sib txuas tsis sib xws. Nyob rau hauv xyoo tas los no, kev tshawb fawb ntawm NAD + yuav luag yog cov thawj coj ntawm SCI cov ntawv xov xwm kev kawm xws li * Kev Tshawb Fawb *, * Xwm *, thiab * Cell *, dhau los ua ib qho kev tshawb pom zoo tshaj plaws hauv kev kho mob, thiab qhuas tias yog ib kauj ruam tseem ceeb hauv tib neeg txoj kev tiv thaiv kev laus thiab txuas ntxiv lub neej.
NAD + cov tshuaj ntxiv tau dhau los ua tiam tshiab ntawm kev tiv thaiv- cov khoom lag luam laus tau nrhiav los ntawm cov zej zog kev tshawb fawb, cov neeg muaj nyiaj, thiab cov tub ua lag luam hauv xyoo tas los no. Lawv tau raug taug qab thiab tshaj tawm los ntawm lub ntiaj teb-cov ntawv xov xwm tshawb fawb xws li *Nature* thiab *Cell*. NASA (National Aeronautics thiab Space Administration) siv NAD + cov tshuaj ntxiv los tiv thaiv cov kws tshawb fawb los ntawm qhov chaw hluav taws xob thiab kho DNA. Cov neeg muaj nyiaj muaj txiaj ntsig zoo xws li Harvard Tsev Kawm Ntawv Kho Mob Xib Fwb David Sinclair, Li Ka-shing, thiab Pan Shiyi tau noj NAD + tshuaj tiv thaiv kev laus thiab kev ua neej ntev.
Yuav ua li cas ntxiv NAD +?
Vim qhov loj ntawm NAD + molecule, qhov ncauj tswj hwm NAD + yog qhov nyuaj rau ncaj qha nqus thiab siv los ntawm cov hlwb los ntawm cov cell membrane.
Los ntawm kev tshawb fawb tas mus li, cov kws tshawb fawb tau tshawb pom tias NAD + tuaj yeem nkag mus rau hauv cov cell membrane yooj yim lossis ncaj qha nkag mus rau hauv cov hlwb ntawm cov hlab ntsha, thiab tom qab ntawd ncaj qha tsim NAD + hauv lub cev, koom nrog cov txheej txheem ntawm cellular antioxidant, stabilizing cellular DNA qauv, thiab kho DNA puas. NAD + supplementation tau dhau los ua lub tswv yim zoo tshaj rau exogenous NAD + supplementation.
Nce NAD + qib
muaj txiaj ntsig zoo rau ntau yam ntawm kev noj qab haus huv:
Ntev:
Ntau qhov kev tshawb fawb tau pom tias kev nce NAD + tuaj yeem txuas ntxiv lub neej ntawm ntau yam kab mob: Poov xab, luv luv -nyob ib leeg-celled kab mob, qhia tau hais tias muaj sia nyob nrog NAD + supplementation, manifested li txhim kho cell replication muaj peev xwm; Cov kev tshawb fawb ntawm cov kab mob qhia tau tias NAD + tuaj yeem txuas lawv lub neej ntev li 10%. Cov teebmeem no kuj txuas mus rau cov tsiaj txhu. Restoring lub cev muaj nuj nqi:
Hauv kev tshawb fawb tsis ntev los no ntawm cov txiv neej laus, NAD + ntxiv tau nce qib NAD + hauv lub cev los ntawm 59% tom qab tsuas yog ob teev, thaum cov cim ntawm oxidative kev nyuaj siab poob qis. Hauv txoj kev tshawb no, cov txiv neej lub isometric nqaij torque ncov (ib qho kev ntsuas ntawm cov leeg nqaij) txhim kho los ntawm 8%, thiab kev tawm dag zog- ntsig txog qaug zog tau txo los ntawm 15%.
Optimizing hlwb ua haujlwm:
Kev tshawb fawb ntawm nas qauv ntawm Alzheimer's kab mob tau pom tias NAD + supplementation tuaj yeem txhim kho tus mob. Hauv kev tshawb fawb tsis ntev los no, nws thim rov qab kev paub tsis meej hauv cov nas, yog li txhim kho kev nco.
Nyob rau hauv lub hlwb ntawm cov tsiaj no, cov pathology (amyloid plaques) pom nyob rau hauv lub hlwb ntawm Alzheimer tus neeg mob kuj raug txo. Cov kev tshawb fawb yav dhau los kuj tau pom cov txiaj ntsig zoo sib xws.
NAD+ IV Drip Anti-Kev Kho Mob Laus
Kev rog rog thiab cov kab mob metabolic: Sirtuins txhim kho cov metabolism thiab pab tiv thaiv qhov hnyav nce, metabolic syndrome, thiab ntshav qab zib hom 2. Los ntawm kev nce Sirtuin kev ua si, NAD + txhim kho cov metabolism thiab tiv thaiv qhov hnyav nce hauv cov nas; Hauv cov qauv tsiaj ntawm hom 2 mob ntshav qab zib mellitus, qhov kev txhim kho metabolism hauv no pab tswj cov ntshav qab zib thiab tiv thaiv kev puas tsuaj los ntawm hyperglycemia.
Kev noj qab haus huv plawv: Txhim kho cov metabolism thiab poob phaus pab txo qis kev pheej hmoo ntawm cov kab mob plawv. NAD + tseem muaj kev tiv thaiv kev ua haujlwm rau cov hlab plawv. Kev tshawb fawb tsis ntev los no tau tsom mus rau cov nas uas muaj kab mob plawv, uas nws qib NAD + tau txo qis los ntawm 30%. Yog tias tsis kho, lawv feem ntau yuav ua rau lub plawv tsis ua hauj lwm, tab sis NAD + txo qis kev ua haujlwm ntawm lub plawv.
Txhim kho kev pw tsaug zog zoo: Cov qauv pw tsaug zog hloov nrog lub hnub nyoog, thiab ntau qhov teeb meem no yog vim muaj kev cuam tshuam ntawm circadian rhythms uas tswj lub voj voog pw tsaug zog / tsaug zog. NAD + tau pom tias muaj peev xwm sib npaug circadian rhythms los ntawm kev txhawb nqa cov cellular protein tseem ceeb Sirt1. Hauv kev tshawb fawb tsiaj, nas tsis muaj Sirt1 tau txo qis pw tsaug zog zoo. Kev nce qib NAD + tuaj yeem pab nce SIRT1 thiab lwm cov sirtuins, pab kom rov qab pw tsaug zog / tsaug zog. Ntau qhov kev tshawb fawb tau pom tias NAD + ua lub luag haujlwm tseem ceeb hauv kev tawm tsam kev laus ntawm zes qe menyuam thiab txhim kho poj niam kev laus laus, thiab kev tshawb fawb tsis ntev los no los ntawm cov ntawv xov xwm muaj koob npe xws li * Xwm * thiab * Cell * qhia tias NAD + kuj tseem muaj txiaj ntsig zoo hauv kev sib ntaus sib tua txiv neej kev laus laus.
Ntsuas Hormones: NAD⁺ ua lub luag haujlwm tseem ceeb hauv kev tswj hwm cov tshuaj hormones thiab txhawb kev sib npaug hauv lub cev endocrine.
Tswj Menopause thiab poob qis: NAD⁺ txoj kev kho muaj ib txoj hauv kev zoo thiab zoo los txo cov tsos mob cuam tshuam nrog kev mob ntshav qab zib thiab tsis muaj libido, xws li kub kub, mus ob peb vas, thiab txo qis kev sib deev.
Txhim kho Libido: Los ntawm kev ua kom muaj zog ntawm tes, NAD⁺ ua rau muaj kev mob siab rau thiab kev ntshaw, ua kom muaj libido thiab rov ua kom muaj kev sib raug zoo.
Txhim Kho Fertility: Optimal cellular function txhawb los ntawm NAD⁺ tuaj yeem txhim kho kev ua me nyuam thiab txhim kho fertility ntawm cov txiv neej thiab poj niam.
Boosting Cellular Function: NAD⁺ supplementation txhawb mitochondrial muaj nuj nqi, nce cellular zog, thiab txhawb tag nrho cov tseem ceeb.
DNA Kho thiab Kho: NAD⁺ ua lub luag haujlwm tseem ceeb hauv DNA kho cov txheej txheem, pab tswj kev ruaj ntseg ntawm genomic thiab txo cov hnub nyoog sib txuam - cuam tshuam txog kev puas tsuaj.
Txhim kho Metabolic Function: Optimized NAD⁺ txhawb kev ua haujlwm metabolic thiab pab tswj cov piam thaj thiab lipid metabolism, yog ib qho tseem ceeb ntawm kev ua neej ntev.
Ua kom muaj kev ntxhov siab ntau ntxiv: NAD⁺ supplementation tau pom tias yuav txhim kho kev ntxhov siab ntawm tes thiab txhawb kev ua haujlwm ntev thiab ua kom ntev nyob rau hauv lub ntsej muag ntawm ib puag ncig thiab oxidative stressors.
Kev Paub Txog Kev Txawj Ntse: Ua kom zoo NAD⁺ tuaj yeem txhawb kev paub txog kev noj qab haus huv los ntawm kev txhawb nqa neuronal resilience thiab kev ua haujlwm, txo qhov kev pheej hmoo ntawm hnub nyoog - cuam tshuam txog kev txawj ntse poob.
Tiv thaiv Hnub Nyoog- Cov Kab Mob Sib Nrauj: Kev tshawb fawb qhia tias NAD⁺ tuaj yeem tiv thaiv ntau lub hnub nyoog- kab mob ntsig txog, suav nrog kab mob plawv, kab mob neurodegenerative, thiab metabolic syndrome.
Txhim khu kev tsim hluav taws xob: NAD⁺ ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm mitochondrial, lub zog ntawm cov hlwb, thiab txhawb kev tsim lub zog zoo thiab kev ua siab ntev.
Txhim kho kev puas siab puas ntsws thiab ua kom pom tseeb: Optimized NAD⁺ tuaj yeem txhim kho kev txawj ntse thiab txhim kho kev puas siab puas ntsws, nco, thiab kev ua haujlwm ntawm lub hlwb tag nrho.
Ua kom muaj zog thiab muaj zog: Txhawb nqa cellular resilience, NAD⁺ pab lub cev tiv taus qhov kev xav tau ntawm kev ua haujlwm ntawm lub cev thiab lub hlwb thiab txhawb kev rov qab sai. Txhim kho kev ua kis las: Kev ua kom zoo NAD⁺ tau pom tias txhim kho kev ua kis las los ntawm kev ua kom cov leeg nqaij ua haujlwm zoo, ua kom muaj zog, thiab txo qis qaug zog.
Optimized Stress Response: NAD⁺ supplementation txhawb lub cev cov txheej txheem kev ntxhov siab, txhawb kev rov ua haujlwm thiab txhim kho kev ua haujlwm hauv kev ntxhov siab.
Txhawb Nqa Lub Neej Ntev thiab Tseem Ceeb: Los ntawm kev txhawb nqa cellular kev noj qab haus huv thiab kho DNA, NAD⁺ cov txheej txheem pab txhawb rau tag nrho lub neej ntev thiab kev noj qab haus huv- ua, ua kom pom tseeb thiab ua haujlwm tau zoo.
Hormone Balance: Optimizing NAD⁺ pab sib npaug cov tshuaj hormones xws li insulin thiab leptin, uas ua lub luag haujlwm tseem ceeb hauv cov metabolism thiab tswj kev noj qab haus huv.
Kev nce qib zog: Los ntawm kev txhawb nqa lub zog ntawm tes, NAD⁺ cov tshuaj ntxiv muab cov roj uas xav tau rau kev ua haujlwm hnyav dua thiab ntev dua, pab hlawv calories thiab txo cov rog, thiab txhawb kev rov zoo.
Mental Focus and Resilience: NAD⁺ tuaj yeem txhim kho kev puas siab puas ntsws thiab kev tiv thaiv, ua rau nws yooj yim dua rau kev noj qab haus huv thiab kev tawm dag zog, txawm tias ntsib teeb meem thiab kev ntxias.
Enhanced Metabolic Function: NAD⁺ maximizes metabolic noj qab haus huv, txhawb nqa calorie hlawv thiab rog metabolism, thiab muab ntau dua yuag kev pab cuam.
Txhim kho Cellular Function: NAD⁺ txhawb nqa cellular noj qab haus huv thiab kho, thiab xyuas kom meej tias cov hlwb koom nrog hauv cov metabolism thiab rog rog ua haujlwm zoo.
Kev tswj ntshav qab zib: Ua kom zoo NAD⁺ txhawb nqa cov piam thaj metabolism thiab insulin rhiab heev, tswj cov ntshav qab zib thiab pab txhim kho glycemic tswj hauv cov neeg mob ntshav qab zib.
Kab mob siab: NAD⁺ ua lub luag haujlwm tseem ceeb hauv daim siab ua haujlwm thiab cov txheej txheem detoxification, thiab yog qhov tseem ceeb rau kev tiv thaiv thiab kho cov kab mob siab xws li tsis yog- kab mob cawv fatty siab (NAFLD) thiab cirrhosis.
Kev rog rog: Los ntawm kev txhim kho mitochondrial muaj nuj nqi thiab txhawb cov roj metabolism, NAD⁺ supplementation tuaj yeem pab tswj qhov hnyav thiab txo cov teeb meem cuam tshuam nrog kev rog.
Cardiovascular Health: NAD⁺ txhawb nqa vascular muaj nuj nqi thiab pab txo cov kev pheej hmoo cuam tshuam nrog cov kab mob plawv, xws li kub siab thiab dyslipidemia.
Metabolic Syndrome: NAD⁺ supplementation hais txog ntau yam xwm txheej ntawm cov kab mob metabolic, suav nrog insulin tsis kam, plab rog, dyslipidemia, thiab kub siab, muab txoj hauv kev zoo rau kev noj qab haus huv metabolic.
