Kev sib txawv ntawm cov qauv: Kev muaj lossis tsis muaj cov pab pawg qab zib yog qhov tseem ceeb
Qhov tseem ceeb sib txawv ntawm ob yog nyob rau hauv lawv cov qauv molecular:
Baicalin: Nws yog tsim los ntawm kev sib xyaw ntawm baicalein nrog glucuronic acid molecule. Nws tuaj yeem suav tau tias yog baicalein nrog "qab zib tail" txuas rau nws.
Baicalein: Qhov no yog "nplua" molecule yam tsis muaj "qab zib Tail".
Qhov "qab zib pawg" no tsis tsuas yog ua rau lawv cov khoom siv tshuaj (xws li solubility) sib txawv, tab sis kuj ncaj qha txiav txim siab lawv cov "hmoov" sib txawv tom qab nkag mus rau tib neeg lub cev.
Qhov sib txawv tseem ceeb: Kev nqus, Kev hloov pauv thiab kev ua haujlwm
Qhov sib txawv tseem ceeb tshaj plaws ntawm ob qhov lus dag nyob rau hauv cov txheej txheem nqus thiab hloov pauv, uas tuaj yeem ua tiav hauv cov lus hauv qab no:
Nws tuaj yeem pom tau tias kaempferol feem ntau suav tias yog cov khoom tseem ceeb uas ua lub luag haujlwm tseem ceeb vim nws txoj kev nqus sai thiab muaj bioavailability siab. Tom qab kev tswj hwm qhov ncauj ntawm kaempferol glucoside, nws yuav tsum "de- qab zib" thiab hloov mus ua kaempferol ua ntej siv los ntawm lub cev. Yog li ntawd, kaempferol tuaj yeem suav tias yog "daim ntawv nquag" ntawm kaempferol glucoside.
Kev sib txawv ntawm kev ua: Kev cuam tshuam ntawm lipophilicity
Vim muaj cov qauv sib txawv, lipophilicity ntawm ob kuj sib txawv. Lub lipophilicity ntawm kaempferol (cov aglycone) muaj zog dua, uas yuav ua rau nws muaj txiaj ntsig zoo hauv kev nkag mus rau hauv cov cell membrane thiab qhia txog kev ua kom muaj zog lom neeg hauv qee qhov kev sim hauv vitro. Txawm li cas los xij, qhov no tsis txhais tau tias kaempferol glucoside tsis muaj txiaj ntsig. Nws tuaj yeem ua raws li qhov ruaj khov "sov daim ntawv" lossis "daim ntawv thauj khoom" ntawm kaempferol hauv lub cev thiab kuj tseem tuaj yeem ua lub luag haujlwm tshwj xeeb hauv cheeb tsam plab hnyuv.
Qhov Tseem Ceeb Ntawm Kev Ua Haujlwm Sib txawv: Kev Ua Ncaj Ncees vs. Cov Kev Cai Tso Tawm Tawm
Raws li kev tshawb fawb tam sim no, lawv cov kev ua tau zoo feem ntau tshwm sim hauv cov hauv qab no:
Qhov ceev thiab cov yam ntxwv ntawm kev tiv thaiv kab mob sib txawv: Hauv kev sim ntawm tes, baicalein feem ntau qhia tau tias muaj zog thiab nrawm dua los tiv thaiv- kev ua rau mob vim tias nws tuaj yeem nkag mus rau hauv cell nucleus ncaj qha thiab sai sai inhibit pro- cov kab mob inflammatory (xws li NF-κB txoj hauv kev). Thaum cov tshuaj tiv thaiv - cov nyhuv inflammatory ntawm baicalin feem ntau yog "indirect", nws nkag mus rau hauv cov hlab ntsha thiab tswj tau ib qho concentration, sib npaug rau ib qho "reservoir", thiab yuav tsum tau hloov mus rau hauv baicalein hauv lub cev ua ntej nws tuaj yeem siv tau. Txawm li cas los xij, cov txheej txheem no kuj ua rau nws muaj tus cwj pwm tsis tu ncua.
Cov tshuaj tiv thaiv kab mob antioxidant muaj qhov sib txawv: Ob leeg tuaj yeem qhib lub xov tooj ntawm tes tus kheej cov kab mob antioxidant (Nrf2 txoj hauv kev), tab sis baicalein, vim nws lipophilicity, tuaj yeem nkag mus rau mitochondria tau yooj yim dua (lub cell lub zog lub Hoobkas) thiab ncaj qha tshem tawm cov dawb radicals nyob ntawd, tiv thaiv lub zog mov. Baicalin, ntawm qhov tod tes, nyiam ua haujlwm hauv cytoplasm thiab cov kua dej ntxiv, xws li "kev tiv thaiv sab nrauv".
Txoj cai ntawm txoj hnyuv flora: Qhov no yog ib qho tseem ceeb sib txawv uas feem ntau overlooked. Ib feem loj ntawm baicalin ncav cuag txoj hnyuv loj thiab dhau los ua "khoom noj" rau cov hnyuv, cuam tshuam rau tag nrho cov metabolism thiab tiv thaiv kab mob los ntawm kev tswj cov kab mob hauv plab hnyuv. Thaum baicalein feem ntau yog absorbed ua ntej mus txog rau txoj hnyuv loj, nws ncaj qha cuam tshuam rau txoj hnyuv muaj me me.
Muaj peev xwm nyiam nyob rau hauv daim ntawv thov scenarios
Raws li qhov sib txawv tau hais los saum no, lawv kuj muaj peev xwm sib txawv hauv cov ntawv thov tshawb fawb:
Rau cov lus teb ceev ceev: Hauv cov qauv uas cov lus teb ceev ceev rau kev puas tsuaj oxidative lossis inflammatory stimuli yuav tsum tau, cov kev tshawb fawb ntawm baicalein yog siab dua.
Rau kev noj qab haus huv txoj hnyuv thiab kev tswj hwm lub cev: Hauv cov xwm txheej cuam tshuam nrog kev kho lub plab hnyuv, kev tswj hwm microbiota, lossis xav tau kev tso tshuaj qeeb, baicalein, vim nws "prodrug" cov yam ntxwv thiab lub hom phiaj plab hnyuv, yuav muaj qhov zoo dua.
Rau kev tiv thaiv kab mob tshwj xeeb: Hauv thaj tsam ntawm kev tiv thaiv kab mob, baicalein muaj kev tshawb fawb ntau dua vim nws muaj peev xwm nkag mus rau cov ntshav tau zoo dua - lub hlwb thaiv thiab ua rau cov paj hlwb sai; thaum baicalein tuaj yeem muab kev txhawb nqa los ntawm kev txhim kho cerebral ntshav ncig lossis tswj kev tiv thaiv kab mob peripheral.
Baicalein 98%
Baicalin 98%yog muab rho tawm los ntawm cov cag qhuav ntawm Scutellaria baicalensis. Nws yog aglycone tsim los ntawm kev tshem tawm glucuronic acid los ntawm baicalin thiab sawv cev rau daim ntawv nquag ntawm huangqin's pharmacological teebmeem hauv vivo. Nws zoo nkaus li cov hmoov daj, ze li insoluble hauv dej tab sis yooj yim soluble hauv cov kuab tshuaj organic xws li ethanol, methanol, acetone, thiab DMSO. Thaum raug cov tshuaj alkaline, nws hloov ntsuab -xim av; nyob rau hauv concentrated sulfuric acid, nws nthuav tawm xim daj nrog ntsuab fluorescence. Vim nws ntau phenolic hydroxyl pawg. nws yog nquag oxidation thiab discoloration, yog li nws yuav tsum tau muab cia rau hauv lub teeb - tiv thaiv, kaw ntim.
Shaanxi Lv Ke Chun Yuan Biotechnology Co., Ltd
Peb qhov chaw nyob
Huaxia Yue ntiaj teb, Weibin District, Baoji City, Shaanxi Province, Suav teb
whatsapp thiab FACEBOOK
86-13992760792
E -mail
sales04@lucynatural.com
