Core Module:
CHO-PEG Segment: PEG saw xaus nrog ib pawg aldehyde (-CHO), imparting hydrophilicity, biocompatibility, thiab reactivity (nws tuaj yeem raug cov tshuaj tiv thaiv condensation nrog amino, hydroxyl, thiab lwm pab pawg).
Chondroitin Sulfate (CS) Ntu: Ib lub ntuj glycosaminoglycan uas muaj kev sib hloov N-acetylgalactosamine thiab glucuronic acid, muaj sulfate ester pawg (-OSO₃⁻), muaj cov tshuaj lom neeg (xws li tiv thaiv{2}} mob, txhawb kev kho mob ntawm tes).
Txoj Kev Sib Txuas: CS khaws nws cov kev ua si lom neeg los ntawm kev tsim cov khoom sib txuas (xws li Schiff bases lossis ester bonds) ntawm pawg aldehyde thiab cov amino pawg lossis lwm pawg reactive (xws li pawg hydroxyl) ntawm CS, lossis los ntawm kev sib txuas los ntawm ether bonds ntawm PEG saw.
2. Cov yam ntxwv cuam tshuam rau kev ruaj ntseg tshuaj
(1) Kub stability
Tsis tshua muaj kub ruaj khov: Thaum khaws cia qhuav thiab tiv thaiv los ntawm lub teeb hauv qab -20 degree, cov qauv ruaj khov nrog qhov tsis tshua muaj kev pheej hmoo ntawm degradation.
Kev kub ntxhov siab:
CS Segment: Tshaj 60 degree, nws tuaj yeem hydrolyze thiab tawg, ua rau cov khoom hnyav molecular tsawg, thiab cov sulfate ester bonds yuav desulfurize, ua rau poob ntawm cov khoom lom lom. PEG ntu: Kub kub yuav ua rau oxidation lossis thermal decomposition ntawm PEG saw, tshwj xeeb tshaj yog nyob rau hauv acidic / alkaline tej yam kev mob.
Aldehyde pawg: Yooj yim oxidized rau carboxylic acid ntawm qhov kub thiab txias, txo reactivity.
(2) pH stability
Cov xwm txheej nruab nrab (pH 7.4): Cov sulfate ester daim ntawv cog lus ntawm CS yog qhov ruaj khov, kev pheej hmoo ntawm PEG saw hydrolysis tsawg, thiab bioactivity yog qhov zoo tshaj plaws khaws cia.
Acid/alkaline tej yam kev mob:
CS ntu: Raws li cov kua qaub muaj zog (piv txwv li, pH <3) lossis lub hauv paus muaj zog (piv txwv li, pH> 10), sulfate ester bond hydrolyzes thiab desulfurizes, txo qhov hnyav molecular; acidic tej yam kev mob yuav txhawb lub condensation cov tshuaj tiv thaiv ntawm aldehyde pawg.
PEG ntu: Nyob rau hauv huab cua pH, ether daim ntawv cog lus yuav hydrolyze, cuam tshuam rau hydrophilicity.
Aldehyde pab pawg: Yooj yim reacts nrog amino pawg nyob rau hauv acidic tej yam kev mob, ruaj khov nyob rau hauv alkaline tej yam kev mob tab sis tej zaum yuav oxidized.
Paub meej
NTAWM: Hmoov
ntim: aluminium ntawv ci hnab, Nruas
ntu: rhizome
Lub caij: tag nrho
Specification: 0.8%
Qhov chaw ntawm keeb kwm: Shaanxi Tuam Tshoj
Cov khoom xyaw tseem ceeb: Valerian
MOQ: 1KG
CAS: 109-52-4
Lub sij hawm xa tuaj: li 3-5 hnub
(3) Oxidative stability
CS ntu: Cov pab pawg sulfate ester thiab hydroxyl pawg tau yooj yim oxidized los ntawm ROS (xws li, H₂O₂, · OH), ua rau kev puas tsuaj thiab txo qis bioactivity.
PEG ntu: Muaj zog oxidants (piv txwv li, hydrogen peroxide) tuaj yeem ua rau cov saw tawg. Aldehyde pawg: Yooj yim oxidized rau carboxylic acid, txo reactivity.
(4) Enzymatic stability
CS ntu: tuaj yeem degraded los ntawm chondroitinase (piv txwv li, chondroitinase ABC), tso cov khoom hnyav molecular; Tus nqi enzymatic yuav tsum tau soj ntsuam nyob rau hauv physiological ib puag ncig.
PEG ntu: ruaj khov rau cov enzymes, tab sis cov ester / amide daim ntawv cog lus ntawm cov chaw sib txuas yuav raug hydrolyzed los ntawm esterases.
(5) Hydrolytic stability
Ester/amide bonds: Tej zaum yuav maj mam hydrolyze nyob rau hauv muaj dej, tshwj xeeb tshaj yog nyob rau hauv acidic/alkaline los yog siab - kub.
Acetal / Schiff puag: Dynamic covalent bonds tau yooj yim hydrolyzed nyob rau hauv acidic tej yam kev mob, cuam tshuam cov qauv kev ntseeg.
(6) Lub teeb ruaj khov
UV teeb: Tej zaum yuav ntxias cov duab-oxidation ntawm aldehyde pawg lossis degradation ntawm PEG chains; yuav tsum khaws cia hauv qhov tsaus ntuj.
Shaanxi Lv Ke Chun Yuan Biotechnology Co., Ltd
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