Khoom Description

Txoj Kev 316606 los tiv thaiv cov plaub hau yog ib qho kev xaiv thiab muaj zog heev sFRP-1-specific inhibitor, thiab nws kuj yog ib qho tseem ceeb me me molecule raw khoom uas tswj Wnt / -catenin signaling txoj kev. Nws cov khoom xyaw tseem ceeb yog cov ntshiab WAY 316606 monomer, tsis muaj cov khoom ntxiv lossis cov xim sib xyaw ua ke. Cov khoom xyaw yog yooj yim thiab ntshiab, nrog cov khoom tsim tawm ruaj khov thiab tsis sib xws, thiab yuav tsis cuam tshuam nrog cov ntaub ntawv sim lossis kev tsim cov nyhuv los ntawm impurities. Nyob rau hauv cov txheej txheem cia nyob rau hauv chav tsev kub, WAY 316606 yog ib tug ntshiab dawb crystalline hmoov zoo, nrog ib tug nplua thiab xoob hmoov zoo nkauj thiab uniform dryness. Tag nrho cov ntxhiab tsw ntawm cov khoom siv raw yog qhov tsis tshua muaj tshwm sim, nyob rau hauv qhov tsis muaj ntxhiab tsw, thiab tsuas yog me ntsis me me molecule raw khoom tsw tuaj yeem pom thaum ze ze. Cov yam ntxwv tawg ntawm Txoj Kev 316606 los tiv thaiv cov plaub hau yog qhov tseeb thiab ruaj khov. Nyob rau hauv chav tsev kub, nws yuav luag insoluble nyob rau hauv cov dej ntshiab; nws muaj cov solubility zoo heev hauv DMSO, thiab tuaj yeem ua tau sai thiab yaj tag nrog kev pab ultrasonic; nws yog me ntsis soluble hauv cawv thiab methanol thiab lwm yam aliphatic kuab tshuaj, thiab cov nyhuv dissolution tuaj yeem txhim kho nrog kev pab cua sov; Nws tuaj yeem yaj me ntsis hauv DMF. Cov kev daws teeb meem tom qab kev sib cais yog qhov tseeb thiab pob tshab, thiab kev ruaj ntseg ntawm qhov system yog qhov zoo heev.

Specification

Khoom npe	Txoj kev 316606 tiv thaiv plaub hau
CAS Nr.	915759-45-4
Purity	99%
Qhov tshwm sim	Dawb hmoov
Daim ntawv thov	tiv thaiv plaub hau
Pob	hnab yas
Cia	Khaws rau hauv lub thawv kaw hauv qhov chaw txias thiab qhuav, qis dua 5ºC.
Hnub tim rov kuaj dua	2 xyoo

COA

Cov khoom	Specifications	Cov txiaj ntsig
Qhov tshwm sim	Yuav luag dawb los yog dawb hmoov	Dawb hmoov
Melting Point	100~106ºC	102.5~104.5ºC
Poob Thaum Qhuav	Tsawg dua lossis sib npaug li 0.1%	0.055%
Hnyav Hlau	Tsawg dua lossis sib npaug li 20ppm	<20ppm
Chromatographic purity Ib qho impurity	Tsawg dua lossis sib npaug li 1.0%	0.32%
Tag nrho impurities	Tsawg dua lossis sib npaug li 1.0%	0.78%
Residue Solvents	Ethanol<0.2%	Ua raws
Kev ntsuam xyuas (HPLC)	Ntau dua lossis sib npaug li 99.0%	99.27%
Xaus	Cov khoom ua tau raws li hauv -cov lus qhia hauv tsev.

Muaj nuj nqi

WAY 316606 tuaj yeem xaiv khi rau thiab inhibit qhov kev ua ntawm sFRP-1, rhuav tshem cov blockade ntawm cov plaub hau kev loj hlob. Nws tuaj yeem ua kom ntev ntev - dormant thiab stagnant - cov hauv paus plaub hau loj hlob ntawm qib cellular, ua tiav cov teeb meem ntawm cov plaub hau follicle inertia uas tsoos roj tswj thiab DHT-thaiv cov khoom xyaw tsis tuaj yeem hais. Nws tshwj xeeb txhim kho cov plaub hau tawv tawv thinning thiab zoo, muag plaub hau teeb meem.

WAY 316606 tuaj yeem txhawb kev loj hlob thiab kev sib txawv ntawm cov plaub hau follicle qia hlwb, ua kom cov plaub hau follicle metabolism, ncua lub sij hawm loj hlob ntawm cov plaub hau, thiab txo cov plaub hau follicle so lub sij hawm los ntawm activating Wnt core txoj kev loj hlob. Nrog ntev - siv sijhawm, nws tuaj yeem ua kom cov kab ntawm cov plaub hau tuab, ua kom cov plaub hau muaj sia nyob, ua rau cov plaub hau tshiab tuab dua thiab ntom ntom, thiab tseem ua rau cov hauv paus plaub hau ruaj khov thiab txo cov teeb meem ntawm cov plaub hau tsis tu ncua thiab cov plaub hau tawg. Tsis zoo li cov khoom xyaw zoo tib yam uas tsuas muaj qhov cuam tshuam tsis zoo xws li tswj cov roj thiab tiv thaiv cov plaub hau, WAY 316606 nquag ua kom rov tsim dua tshiab thiab ua tiav cov txiaj ntsig ntawm kev ua kom cov plaub hau nce.

Qhov zoo tshaj plaws ntawm WAY 316606 yog nws qhov kev ua tau zoo heev. Nws tshwj xeeb ua rau sFRP-1 lub hom phiaj qhov chaw thiab yuav luag tsis muaj kev cuam tshuam nrog lwm cov proteins thiab cov tshuaj hormones hauv lub cev. Nws tsis cuam tshuam rau cov tshuaj hormones li qub thiab cellular metabolic kev txiav txim ntawm tib neeg lub cev. Nws daim ntawv thov sab nraud yog me me thiab tsis yog - khaus, thiab nws tsis muaj kev pheej hmoo cuam tshuam nrog cov tshuaj tiv thaiv ib txwm muaj -androgen raw khoom. Nws yog qhov tsim nyog rau lub sij hawm ntev - thiab ua kom zoo zoo ntawm tawv taub hau thiab muaj kev nyab xeeb qib siab tshaj rau feem ntau cov khoom xyaw ntawm cov plaub hau kev loj hlob.

WAY 316606 kuj tseem tuaj yeem koom nrog cov txheej txheem physiological xws li kev tswj cov pob txha metabolism thiab kho cov kab mob epithelial. Nws tuaj yeem pab txhim kho cov teeb meem ntsig txog cov hlwb puas thiab cov metabolism qeeb, thiab muaj ntau yam kev tshawb fawb kho cov nqi, tsim nyog rau kev tshawb fawb tob hauv ntau qhov chaw.

Daim ntawv thov

Txoj kev loj hlob ntawm siab -kawg sib txawv cov khoom tu plaub hau tam sim no yog qhov tseem ceeb tshaj plaws kev lag luam scenario. Ntau tus neeg txawv teb chaws nruab nrab-rau- siab- kawg cov khw muag plaub hau yuav muab WAY 316606 nrog RU58841, dutasteride thiab cog cov plaub hau loj hlob extracts rau siv, tsim kom muaj "roj tswj thiab tiv thaiv plaub hau poob + txoj hauv kev rov tsim dua tshiab" multi-kev tu plaub hau zoo-end

WAY 316606 yog siv dav hauv kev tshawb fawb tshwj xeeb hauv cov tsev kawm qib siab thiab cov chaw kuaj mob hauv tsev thiab txawv teb chaws, cov tuam txhab tshuaj, thiab cov chaw tshawb fawb lom neeg. Nws yog tsuas yog siv rau kev txheeb xyuas ntawm Wnt signaling pathway mechanism rau cov plaub hau follicle regeneration pharmacological kev tshawb fawb, pob txha metabolism hauv kev sim, thiab qia cell sib txawv thiab kho cell hauv ntau yam kev tshawb fawb txog kev tshawb fawb.

Hauv cov tuam txhab kev tswj hwm cov plaub hau thiab kev kho mob zoo nkauj, WAY 31660 feem ntau yog tsim los rau hauv siab -kawg kho cov plaub hau follicle activation tov thiab cov plaub hau thinning kho cov ntsiab lus.